1878
*US Congress passed Federal Quarantine Legislation in April *A yellow fever epidemic struck the Mississippi Valley from July to October. New Orleans and Memphis were hard hit. Over 20,000 people died.
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In response to continued yellow fever outbreaks over several years, Congress passed legislation that made quarantine a Federal responsibility. Before then, quarantine was left up to state and local jurisdictions. Of course, little in the way of funding was appropriated.
Later in 1878, a very serious epidemic of yellow fever swept the Mississippi Valley. There were approximately 100,000 cases of the disease, and over 20,000 deaths. People evacuated the towns and cities in panic, business came to a standstill, and severe quarantine measures were invoked, to no avail.
Robert Lebby was the state quarantine officer at the port of Charleston, beginning in 1868. The State Health officer ran the state’s quarantine system, based in Charleston Harbor, with an annual state appropriation of $1,000. Dr. Lebby’s report for 1879:
It affords me unfeigned pleasure to inform the representatives of the people that, while pestilence and death have again been recorded at Memphis, New Orleans and other places in the Mississippi Valley, the cities and towns on our seacoast have been entirely free from yellow fever, and the endemic fevers of this climate have prevailed but to a limited extent.  The improvement in the general health may be attributed to the general interest and improvement in sanitary service and the watchfulness and energy of municipal officers in cleaning and removing the elements likely to produce disease.  The quarantine elements have been rigidly enforced by your officers at the several stations...
The number of vessels visited and examined at this station [Charleston Harbor] was one hundred and eleven (111), a decrease of twenty-seven...Many of the vessels were from infected South American and Cuban ports.  The crews on arrival were healthy and remained so during their detention at quarantine.  The last year has been an exception to former years; not a sick man has been brought into port from any infected ports; the crews have been generally in good, healthy condition.

Reports and Resolutions of the General Assembly of the state of South Carolina at the regular session of 1879 Columbia SC Calvo & Patton, state printer, 1879.