Colonial Times
Colonial Times 1670-1782
The history of public health in South Carolina begins with the earliest permanent European settlement. Charleston, founded in 1670, was the largest population center of the English settlements in South Carolina. The historical records from Charleston give us a picture of death and misery from episodes of widespread contagious and vector-spread diseases, including smallpox, diphtheria, malaria, and yellow fever. These  recurrent epidemics of deadly diseases swept through the settlements and the native American tribes and killed many people, with terrible suffering.
The causes of the diseases were not known - their association with climate, with the seasons of the year, with swamps  or with the arrival of ships was noted.
Preventive measures of quarantine and improved sanitation were implemented erratically and medicine had few effective treatments.