Chemistry Division (PHL)

Analytical Chemistry Section

If you have been exposed to a poisonous chemical agent, IMMEDIATELY contact the Palmetto Poison Center at 1-800-222-1222.

The Level 1 and Level 3 laboratories in the Analytical Chemistry section are part of the Centers for Disease Control and Prevention (CDC) Laboratory Response Network for Chemical Threats (LRN-C).

Level 1 Laboratory

The Level 1 laboratory, one of only 10 in the USA, serves as a surge-capacity laboratory for the CDC to provide rapid and effective analysis of clinical specimens for chemical threat agents likely to be used in a terroristic event. These laboratory measurements will support the response to a public health emergency involving chemical threat agents by guiding emergency medical care and public health emergency management through the identification of the chemical threat agent(s) used and the determination of an individual's level of exposure. The Level 1 laboratory has the capacity to analyze for a wide spectrum of chemical classes and metabolites, e.g. metals, volatile organic compounds (VOCs) and nerve agent metabolites, to name a few. An analysis is done on human specimens, usually blood or urine, to detect exposure to toxic substances which are reported to local and/or regional healthcare providers and the CDC. The instrument platforms used for analysis include:

  • Liquid chromatography (LC)
  • Gas chromatography (GC)
  • Inductively coupled plasma (ICP)
  • Mass spectrometry (MS)

The Level 1 laboratory maintains readiness through continuous method optimization, stocking required surge materials and assuring staff competency through training and proficiency testing.

Chemical Agent Fact Sheets

Level 3 Laboratory

The Level 3 laboratory participates in outreach to South Carolina (SC) public health emergency preparedness partners, e.g. hospitals and first responders, to educate in the capabilities of the Level 1 laboratory and/or train in procedures pertaining to safe and effective specimen collection, handling and shipping during and after a public health emergency involving chemical threat exposure(s). The Level 3 laboratory seeks to integrate the South Carolina LRN-C laboratories in the procedures and response exercises that are crucial to the overall emergency preparedness for the state. The training is usually held at the partner facility, or occasionally at the SC Public Health Laboratory (PHL). The topics covered may include:

  • Background information on the Level 1 laboratory testing capacity
  • Brief description of chemical threat agents
  • Role of the CDC, Level 1 laboratory, and hospitals in a chemical terrorism/exposure event
  • Clinical specimen collection, handling and shipping protocol
  • Chain-of-custody protocol

A Chemical Exposure Response Kit is provided for each organization attending the training. The kits are customized for the training participants. Certificates are awarded upon completion of the training. For more information, or to set up a training session, please contact the laboratory via telephone at 1-803-896-0886 or e-mail the Analytical Chemistry supervisor or Chemistry Division Director listed below.

The chemical threat emergency response preparation in the Analytical Chemistry section is supported by the CDC Public Health Emergency Preparedness Cooperative Agreement.

Useful Information

Sample Collection, Packaging and Shipping Information for Health Professionals

Important Contacts

Analytical Chemistry Section Contacts

Newborn Screening (NBS)

In accordance with SC regulations, all infants born in the state are required by law to be screened for a panel of metabolic, hormone/enzyme, and genetic disorders. Parents may opt out only for religious objections. The disorders on the screening panel are based on the Secretary of U.S. Department of Health and Human Services Recommended Universal Screening Panel (RUSP). The SC NBS laboratory screens for most conditions on the RUSP; newly added conditions are in various stages of implementation. The NBS laboratory screens for the classes listed below:

  • Amino Acid Disorders
  • Organic Acid Disorders
  • Fatty Acid Disorders
  • Hormone and Enzyme Disorders
  • Hemoglobinopathy Disorders
  • T-cell Related Disorders
  • Other Genetic Disorders

Refer to the SC NBS website for the list of specific conditions on the screening panel and related information sheets.

Preferably 24 - 48 hours after birth, a series of small drops of blood from the heel of an infant are placed on a filter paper card that contains the demographic information for the infant. The filter paper cards containing the blood spots are dried, then shipped to the NBS laboratory. The analysis for the screening panel is done on small samples of the dried blood spots (DBS). The instrument platforms used by the NBS laboratory include:

  • Tandem Mass Spectrometry (MS/MS)
  • Fluoroimmunoassay
  • Enzymatic assay
  • High Performance Liquid Chromatography (HPLC)
  • Isoelectric Focusing
  • Molecular assay

The laboratory sends the results of the analyses to the health care provider/facility that submitted the DBS filter paper card to the laboratory. The purpose of newborn screening is to identify infants at risk for a screened disorder. As with any laboratory test, both false positive and false negative results are possible. Thus, screening results are insufficient information upon which to base definitive diagnosis or treatment. Thus, when an abnormal screening result is obtained in the newborn screening laboratory, the Department of Health and Environmental Control (DHEC) Children's Services Division is notified. Children's Services personnel consult with clinical specialists and contact parents and infant healthcare providers. Families with infants with an abnormal screen are linked with or advised of the appropriate clinical follow-up for additional testing for possible diagnosis and treatment.

Useful Information

NewSTEP's website, a national newborn screening resource center

Newborn Screening Section Contacts

Children's Services Division Contacts

Clinical Chemistry Section

The Clinical Chemistry section provides clinical specimen testing support for two DHEC programs that serve SC communities. The Tuberculosis (TB) Control Program submits specimens for testing for a panel of chemistries which include but are not limited to Glucose, Creatinine and Alkaline Phosphatase. The Sexually Transmitted Diseases/HIV Prevention Program submits specimens for testing for a lymphocyte subset and complete blood count panels which includes but are not limited to CD4, CD8, red blood cell counts and platelet counts. The instrument platforms used by the Clinical Chemistry section include:

  • Chemistry analyzer
  • T-cell counters
  • Flow cytometer

For a complete list of testing services offered by the Clinical Chemistry section, refer to the Lab Services Guide (pdf).

Clinical Chemistry Section Contacts

Tags

Health Public Health Laboratory