- Upstate (Abbeville, Anderson, Cherokee, Greenville, Greenwood, Laurens, McCormick, Oconee, Pickens, Spartanburg and Union Counties)
- Midlands (Aiken, Barnwell, Chester, Edgefield, Fairfield, Georgetown, Horry, Kershaw, Lancaster, Lexington, Newberry, Richland, Saluda and York Counties)
- Pee Dee (Chesterfield, Clarendon, Darlington, Dillon, Florence, Lee, Marion, Marlboro, Sumter and Williamsburg Counties)
- Lowcountry (Allendale, Bamberg, Beaufort, Berkeley, Calhoun, Charleston, Colleton, Dorchester, Hampton, Jasper and Orangeburg Counties)
Select a Disease to see the mortality rates among South Carolina residents by Region.